Primary hyperparathyroidism (PHPT) is a hereditary disease in which the regulation of calcium levels in the body is disturbed. Possible consequences are an increasing weakening of the bones, kidney problems and even kidney failure as well as other metabolic disorders.

A variant in the SIRT6 gene was found in the Wolfspitz/Keeshond that is associated with the disease. This is inherited in an autosomal dominant manner. The late onset of the disease is particularly challenging for breeders, as the symptoms of PHPT usually only become apparent after the age of 8 and therefore often at a time when the dogs have already been used for breeding. The genetic test enables early identification of affected animals and supports breeders and owners in responsible breeding selection and prevention.