A genetic variant in the thyroperoxidase gene causes primary congenital hypothyroidism in cats. Affected cats show dysproportional dwarfism.

In some cats the growth retardation is obvious, while in others it is less noticeable. Other signs may include goiter with bilateral enlargement of both lobes of the thyroid gland, mental sluggishness, constipation and delayed tooth eruption. Serum total T4 concentrations are in a low to low-normal range, while TSH concentrations are abnormally high. Congenital hypothyroidism is usually diagnosed at a young age. Supplementation with L-T4 leads to a clinical improvement as well as to an increase in serum T4 and a decrease in TSH concentrations.

Are you interested in the genetic make-up of your cat? Congenital hypothyroidism is now also included in the comprehensive LABOGenetics XXL Cat combination. Over 50 genetic variants are being studied here. You will receive information on hereditary diseases, genetic risk factors, coat colours and coat characteristics. The determination of the genetic blood group is, of course, also included. LABOGenetics XXL Cat is available for cats of all breeds and mixes.