Cystinuria

General description

Cystinuria is caused by a defective transport of the amino acid cystine in the kidney tubules. Dogs suffering from Cystinuria suffer repeated urinary tract inflammations, and are at risk for urinary blockage, which can, if not treated promptly, lead to kidney failure, bladder rupture, and death.

Breeds

Australian Cattle Dog, Australian-Labradoodle (Cobberdog), Continental Bulldog, English Bulldog, French Bulldog, Labradoodle, Labrador Retriever, Landseer, Mastiff, Miniature Pinscher, Newfoundland, Olde English Bulldogge

Cystinuria type IIA

In Australian Cattle Dogs, the disease is inherited as a dominant trait whereby homozygous affected dogs has more severe symptoms than heterozygous carriers.

Cystinuria type III

Cystinuria in the breeds Continental Bulldog, English Bulldog, French Bulldog, Mastiff and Olde English Bulldogge differs in that the disease becomes clinically apparent only in homozygously affected, intact, i.e. non-neutered, males. In these breeds, the occurrence of symptoms is linked to male sex hormones (androgens).

Cystinuria type IA - Labrador Retriever

The symptoms described in the breed Labrador Retriever can be found in the text above.

Cystinuria type IA - Newfoundland

The symptoms described in the breeds Landseer and Newfoundland can be found in the text above.

Cystinuria type IB

The symptoms described in the Miniature Pinscher can be found in the text above.