Necrotizing meningoencephalitis (NME/PDE)
Necrotizing meningoencephalitis (NME/PDE)
General description
Pug dog encephalitis is an inflammatory disease of the brain. First symptoms usually appear at the age of six months to three years and include disorientation, instability and seizures. Affected dogs hold their head tilted to one side or shake their heads, they wobble, show an unsteady gait, stumble and fall. Some walk in circles without being able to stop or scratch the head in an attempt to release pressure and pain. Last dementia and coma occur.
Breeds
Pug
Order details
| Test number | 8429 |
| Abbreviation | NME/PDE |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | neurological |
| Inheritance | autosomal recessive with incomplete penetrance; a risk factor associated with PDE is detected. |
| Age of onset | 6 months- 3 years |
| Causality | High-risk factor |
| Gene | DLA-DPB1 |
| Mutation | DEL |
| Literature | OMIA:001470-9615 |
Detailed description
Pug dog encephalitis is an inflammatory disease of the brain, that is genetically transferred in pugs. This auto-immune disease appears to have no infectious cause, but results from a genome driven immune-response, which attacks cells of the central nervous system. First symptoms usually appear at the age of six months to three years and include disorientation, instability and seizures. Affected dogs hold their head tilted to one side or shake their heads, they wobble, show an unsteady gait, stumble and fall. Some walk in circles without being able to stop or scratch the head in an attempt to release pressure and pain. Last dementia and coma occur. Dogs with encephalitis die 3-6 months after the onset of symptoms.
