Musladin-Lueke syndrome (MLS)
Musladin-Lueke syndrome (MLS)
General description
Musladin-Lueke Syndrome (MLS) manifests with extensive fibrosis of the skin and joints. Arthrosis, stiffness, short outer digits as well as a typical flat head shape with higher ear set and slanted eyes are characteristic for this disease. Affected dogs walk upright on their front feed in what resembles a ballerina stance. Additionally, they show a “happy” temperament.
Breeds
Beagle
Order details
| Test number | 8411 |
| Abbreviation | MLS |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | skeletal |
| Inheritance | autosomal recessive |
| Age of onset | 2-4 months |
| Causality | causally |
| Gene | ADAMTSL2 |
| Mutation | C-T |
| Literature | OMIA:001509-9615 |
Detailed description
Musladin-Lueke syndrome (MLS) manifests with extensive fibrosis of the skin and joints. As puppies, affected dogs fail to thrive. By one year of age the disease stabilizes whereby arthrosis, stiffness, short outer digits as well as a typical flat head shape with higher ear set and slanted eyes are characteristic for this disease. Affected dogs walk upright on their front feed in what resembles a ballerina stance. Additionally, they show a “happy” temperament.
