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Dwarfism (growth-hormone deficiency) - Chihuahua

General description

In the breed Chihuahua, a genetic variant of the GH1 (growth hormone) gene has been found to be associated with dwarfism and hypoglycemia. A six-month-old Chihuahua dog, homozygous for the described variant, showed proportionate dwarfism, retained puppy hair coat, retained deciduous teeth, open fontanelles and collapsed because of hypoglycemia once every 3 days. Blood tests revealed hypoglycemia, thrombocytosis, hypoproteinemia and elevated alkaline phosphatase activity. Organic abnormalities in the pituitary gland have not been found.

Breeds

Chihuahua

Test number Only available in LABOGeneticsXXL – Dog
Inheritance autosomal-recessive
Gene GH1
Mutation DEL
Literature OMIA:001473-9615