Delayed postoperative hemorrhage (DEPOH) – Deerhound, Greyhound
Delayed postoperative hemorrhage (DEPOH) - Deerhound, Greyhound
General description
A variant in the SERPINF2 gene in Scottish Deerhounds and Greyhounds is associated with an increased risk of developing delayed postoperative hemorrhage (DEPOH). Clinical signs are unexpected, excessive bleeding or bruising starting 1 to 4 days after a surgical procedure with unremarkable results of coagulation screening tests.
Breeds
Deerhound, Greyhound
Order details
| Test number | 8862 |
| Abbreviation | DEPOH |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | hematologic |
| Inheritance | autosomal dominant with incomplete penetrance |
| Causality | High-risk factor |
| Gene | SERPINF2 |
| Mutation | C-T |
| Literature | OMIA:002631-9615 |
Detailed description
A variant in the SERPINF2 gene has been identified in Scottish Deerhounds and Greyhounds that is associated with an increased risk of developing delayed postoperative hemorrhage (DEPOH). Clinical signs are the unexpected, excessive bleeding or bruising starting 1 to 4 days after a surgical procedure. The symptoms vary from frank bleeding from the wound, to excessive and also progressive bruising of the skin surrounding the wound and hemoabdomen. The results of coagulation screening tests like the measurements of prothrombin time, activated partial thromboplastin time and von Willebrand factor antigen, as well as platelet counts were unremarkable.
Compared to dogs not carrying the marker variant, dogs with two variant alleles as well as dogs with one variant allele show an increased risk of developing DEPOH.
