Larynxparalyse mit Polyneuropathie Typ 3 (LPPN3)
Larynxparalysis with polyneuropathy type 3 (LPPN3)
General description
Dogs affected by LPPN3 often show breathing difficulties as the first sign noticed by loud and gagging breathing and leading to laryngeal paralysis. Other typical signs of a polyneuropathy such as gait disorders can also occur.
Breeds
Australian-Labradoodle (Cobberdog), Great Dane, Labradoodle, Labrador Retriever, Leonberger, St. Bernard
Order details
| Test number | 8685 |
| Abbreviation | LPPN3 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | neurological |
| Inheritance | autosomal recessive |
| Causality | causally |
| Gene | CNTNAP1 |
| Mutation | C-T |
| Literature | OMIA:002301-9615 |
Detailed description
Dogs affected by LPPN3 often show breathing difficulties as the first sign noticed by loud and gagging breathing and leading to laryngeal paralysis. Other typical signs of a polyneuropathy such as gait disorders can also occur. In addition to this mutation, there are other causal mutations that lead to the similar diseases LPN1 or LPN2 in Leonberger.
