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Neuronal ceroid lipofuscinosis (NCL)

General description

NCL is a neurodegenerative disease: the clinical course includes increasing levels of agitation and possible outbursts of aggression, hallucinations, hyperactivity and epileptic fits. Most animals lose their ability to coordinate everyday muscular activities. As the extent of neurodegeneration increases, all affected dogs develop psychological abnormalities and ataxia.

Breeds

American Bulldog, Border Collie, Chihuahua, Chinese Crested Dog, English Setter, Golden Retriever, Goldendoodle, Gordon Setter, Italian Cane Corso, Saluki, Schapendoes, Small Swiss Hound, Tibetan Terrier

Detailed description

NCL is a neurodegenerative disease, caused by lysosomal storage dysfunction. The clinical course includes increasing levels of agitation and possible outbursts of aggression, hallucinations, hyperactivity and epileptic fits. Most animals lose their ability to coordinate everyday muscular activities. As the extent of neurodegeneration increases, all affected dogs develop psychological abnormalities and ataxia.

Neuronal Ceroid Lipofuszinosis CLN1

The symptoms described in the breed Italian Cane Corso can be found in the text above.

Order details
Test number8075
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration7-14 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive
Causalitycausally
GenePPT1 (CLN1)
MutationG-A
LiteratureOMIA:001504-9615

Neuronal Ceroid Lipofuszinosis CLN10

The symptoms described in thebreed American Bulldog can be found in the text above.

Order details
Test number8075
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration7-14 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive
Causalitycausally
GeneCTSD
MutationC-T
LiteratureOMIA:001505-9615

Neuronal Ceroid Lipofuszinosis CLN12 - Tibetan Terrier

The symptoms described in the breed Tibet Terrier can be found in the text above.

Order details
Test number8075
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration7-14 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive
Causalitycausally
GeneATP13A2 (CLN12)
MutationDEL
LiteratureOMIA:001552-9615

Neuronal Ceroid Lipofuszinosis CLN5 - Border Collie

The symptoms described in the breed Border Collie can be found in the text above.

Order details
Test number8075
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration7-14 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive
Causalitycausally
GeneCLN5
MutationC-T
LiteratureOMIA:001482-9615

Neuronal Ceroid Lipofuszinosis CLN5 - Golden Retriever

The symptoms described in the breed Golden Retriever can be found in the text above.

Order details
Test number8075
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration7-14 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive
Causalitycausally
GeneCLN5
MutationDEL
LiteratureOMIA:001482-9615

Neuronal Ceroid Lipofuszinosis CLN7

The symptoms described in the breeds Chihuahua and Chinese Crested Dog can be found in the text above.

Order details
Test number8075
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration7-14 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive
Causalitycausally
GeneMFSD8 (CLN7)
MutationDEL
LiteratureOMIA:001962-9615

Neuronal Ceroid Lipofuszinosis CLN8 - Saluki

The symptoms described in the breed Saluki can be found in the text above.

Order details
Test number8075
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration7-14 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive
Causalitycausally
GeneCLN8
MutationDUP
LiteratureOMIA:001506-9615

Neuronal ceroid lipofuscinosis CLN8 - Setter

The symptoms described in the breeds English Setter and Gordon Setter can be found in the text above.

Order details
Test number8075
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration7-14 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive
Causalitycausally
GeneCLN8
MutationT-C
LiteratureOMIA:001506-9615