Canine leucocyte adhesion deficiency (CLAD)
Canine leucocyte adhesion deficiency (CLAD)
General description
Canine Leukocyte Adhesion Deficiency (CLAD) is a fatal immunodeficiency disease leading to premature death because of severe multiple infections. Affected dogs show severe omphalophlebitis, skin infections, osteomyelitis and gingivitis.
Breeds
Irish Red Setter, Irish Red and White Setter
Order details
| Test number | 8012 |
| Abbreviation | CLAD |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | immunological |
| Inheritance | autosomal recessive |
| Age of onset | 8-12 weeks |
| Causality | causally |
| Gene | ITGB2 |
| Mutation | C-G |
| Literature | OMIA:000595-9615 |
Detailed description
Canine leukocyte adhesion deficiency (CLAD) is a fatal immunodeficiency disease found in Irish Setters. The condition is caused by mutation in a gene encoding a leucocyte surface molecule, leading to a dysfunction of the granulocytes. Therefore, the cell-cell adhesion events are disturbed. Because their healing capacities are impaired, the affected dogs show severe infections of omphalophlebitis, skin infections, osteomyelitis and gingivitis. They die early in life from multiple severe infections, even if treated with massive doses of antibiotics. At the age of 8 -12 weeks, a swelling of the jawbones and joint inflammations could be observed leading to the CLAD typical unsteady gait.
