Leukoencephalomyelopathy (LEMP)

General description

Typical symptoms of LEMP are coordination and movement disorders. Only a few months after the first symptoms, the affected dogs will not be able to stand up or to walk any more. The age of onset is about 1 – 3 years.

Breeds

Great Dane, Leonberger, Rottweiler

Detailed description

Leukoencephalomyelopathy (LEMP) is a juvenile-onset neurodegenerative disorder in the white matter of the central nervous system (CNS). Due to destructions of the myelin sheath, which protectively surrounds the nerve fibres, the nerve conduction is interrupted. Typical symptoms of LEMP are coordination and movement disorders. Only a few months after the first symptoms, the affected dogs will not be able to stand up or to walk any more. In the breeds Leonberger, Rottweiler and Great Dane, variants in the NAPEPLD gene have been identified to be associated with LEMP. NAPEPLD encodes for an enzyme of the endocannabinoid system, which seems to be involved in myelin homeostasis, CNS development and to have a neuroprotective function. The age of onset is about 1 – 3 years and the disease is inherited in an autosomal recessive manner. Since about 1% of the examined dogs without symptoms are tested as homozygous affected, it is assumed that the penetrance is reduced and the influence of modifier genes or factors is expected.

Leukoencephalomyelopathy (LEMP) - Great Dane, Rottweiler

The symptoms described in this breed can be found in the text above.

Order details
Test number8283
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration3-14 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive
Age of onset1-3 years
Causalitycausally
GeneNAPEPLD
MutationINS
LiteratureOMIA:001788-9615

Leukoencephalomyelopathy (LEMP) - Leonberger

The symptoms described in this breed can be found in the text above.

Order details
Test number8283
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration3-14 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive with incomplete penetrance
Age of onset1-3 years
Causalitycausally
GeneNAPEPLD
MutationG-C
LiteratureOMIA:001788-9615