MDR1 gene variant (Ivermectin hypersensitivity)
MDR1 gene variant (Ivermectin hypersensitivity)
General description
Avermectins are a class of natural products with broad antiparasitic activity. Ivermectin, a prominent member of the avermectin family, is a drug that is used extensively in veterinary medicine to treat infections caused by nematode and arthropod parasites. Neurotoxic symptoms caused by the genetic disease include mydriasis, tremors, ataxia and anorexia. Neurological manifestations of ivermectin in susceptible dogs also include hypersalivation, blindness, coma respiratory compromise and death.
Breeds
Australian Shepherd, Border Collie, Collie (rough/smooth), Elo, German Shepherd Dog, McNab Shepherd, Miniature American Shepherd, Old English Sheepdog, Shetland Sheepdog (Sheltie) , Silken Windhound, Silken Windsprite (Long-Haired Whippet), White Swiss Shepherd Dog, Wäller
Order details
| Test number | 8032 |
| Trivial names | MDR1 defect, ivermectin Intolerance, drug intolerance (MDR1) |
| Abbreviation | MDR1 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | metabolic |
| Inheritance | autosomal recessive; however, carriers with hypersensitivity can also be expected |
| Causality | causally |
| Gene | ABCB1 |
| Mutation | DEL |
| Literature | OMIA:001402-9615 |
Detailed description
Avermectins are a class of natural products with broad antiparasitic activity. Ivermectin, a prominent member of the avermectin family, is a drug that is used extensively in veterinary medicine to treat infections caused by nematode and arthropod parasites. Although ivermectin is generally safe for use in domestic animals, in the 1980s a number of clinical cases with neurological manifestation have been reported after ivermectin treatment. Neurotoxic symptoms include mydriasis, tremors, ataxia and anorexia. These symptoms occur at doses that are 1/200th of the dose required to cause toxicity in other dogs. Neurological manifestations of ivermectin in susceptible dogs also include hypersalivation, blindness, coma respiratory compromise and death.
Dogs with the MDR1 gene variant suffer from multiple intolerance of drugs. An interaction with the multi-drug-resistence-transporter (MDR1) has been proven for more than 100 drugs.
