B-Lokus (seltene Varianten, Allele: b4, be, bh)
B-locus (rare variants, alleles: b4, be, bh)
General description
In addition to the variants bc, bd, and bs that occur in all breeds, there is a rare causative variant b4 in the Australian Shepherd and Miniature American Shepherd breeds, a causative variant be in the Lancashire Heeler, and a causative variant bh in the Husky
Breeds
Australian Shepherd, Lancashire Heeler, Miniature American Shepherd, Siberian Husky
Order details
| Test number | 8639 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-14 working days |
Test specifications
| Literature | OMIA:001249-9615 |
Detailed description
The brown coat color is determined by the TRP1 gene at the B locus. Two allele forms are possible: B (dominant) is responsible for the base color, b (recessive) causes the brown coat color. Two copies of the recessive b-allele are necessary to lighten black to brown. In yellow dogs, b has no effect on the coat color, but the nose and paw pads change from black to brown when b is homozygous.
In addition to the variants bc, bd, and bs that occur in all breeds, there is a rare causative variant b4 in the Australian Shepherd and Miniature American Shepherd breeds, a causative variant be in the Lancashire Heeler, and a causative variant bh in the Husky.
In the case of the French Bulldog, the genetic variant "cocoa" also causes a brown coat color that is not visually distinguishable from the previously known coat colors on the B-locus.
