C3-Defizienz (C3)
C3 deficiency (C3)
General description
The third component (C3) of the complement system plays an important role in the immune response to pathogens. Affected dogs exhibit higher susceptibility to bacterial infections and often develop glomerulonephritis.
Breeds
Brittany Spaniel
Order details
| Test number | 8184 |
| Abbreviation | C3 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | immunological |
| Inheritance | autosomal recessive |
| Causality | causally |
| Gene | C3 |
| Mutation | DEL |
| Literature | OMIA:000155-9615 |
Detailed description
The third component (C3) of the complement system plays an important role in the immune response to microbes like bacteria, fungi or parasites. The causative mutation prohibits the formation of functional C3 units and the chain of defence mechanisms is broken. Affected dogs exhibit higher susceptibility to bacterial infections. Glomerulonephritis, caused by C3-deficiency dependant cell death in the complement system, is often diagnosed for those dogs.
