Late onset Ataxie (LOA)
Late onset ataxia (LOA)
General description
Clinical signs of Late Onset Ataxia are loss of balance and minor incoordination of gait while later symptoms can be a progressive incoordination or a complete loss of mobility. Affected dogs will show first indications of the ataxia at the age of 6-12 months.
Breeds
Jack Russell Terrier, Parson Russell Terrier
Order details
| Test number | 8493 |
| Abbreviation | LOA |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | neurological |
| Inheritance | autosomal recessive |
| Age of onset | 6-12 months |
| Causality | causally |
| Gene | CAPN1 |
| Mutation | C-T |
| Literature | OMIA:001820-9615 |
Detailed description
This disease is caused by a mutation in the calcium activated neutral proteinase 1 (CAPN1)-gene. Affected dogs will show first indications of the ataxia at the age of 6-12 months. First clinical signs are loss of balance and minor incoordination of gait while later symptoms can be a progressive incoordination or a complete loss of mobility.
