Gallbladder mucoceles (GBM)
Gallbladder mucoceles (GBM)
General description
Gallbladder mucoceles causes mucinous hyperplasia of the gallbladder wall and accumulation of mucus resulting in an extended gallbladder. Clinical signs occur in older dogs showing vomiting, anorexia, lethargie, icterus and abdominal pain.
Breeds
American Cocker Spaniel, Cairn Terrier, English Cocker Spaniel, Pomeranian, Shetland Sheepdog (Sheltie)
Order details
| Test number | 8323 |
| Abbreviation | GBM |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | systemic |
| Inheritance | autosomal dominant with variable penetrance |
| Causality | causally |
| Gene | ABCB4 |
| Mutation | INS |
| Literature | OMIA:001524-9615 |
Detailed description
Gallbladder mucoceles are caused by a mutation in the ABCB4 gene. This mutation leads to mucinous hyperplasia of the gallbladder wall and accumulation of mucus resulting in an extended gallbladder. Undetected gallbladder mucoceles can lead to cholecystitis and rupture of the gallbladder. Clinical signs occur in older dogs showing vomiting, anorexia, lethargie, icterus and abdominal pain.
