Haemophilia A (Factor VIII deficiency)

General description

The clinical signs include haematomas of large sizes, bleeding of the nose, skin, muscles and joints. If the disease is severe and no precautions are taken, affected dogs can bleed to death after surgery or injuries.

Breeds

Boxer, German Shepherd Dog, Labrador Retriever, Old English Sheepdog, Rhodesian Ridgeback

Detailed description

The underlying pathomechanism of Haemophilia A is a lack or decreased activity of factor VIII that plays a critical role in the coagulation cascade. Affected dogs present with hemorrhage that can vary from mild to severe depending on the degree of the disease. The clinical signs include haematomas of large sizes, bleeding of the nose, skin, muscles and joints. If the disease is severe and no precautions are taken, affected dogs can bleed to death after surgery or injuries.

Haemophilia A - Boxer

The symptoms described in this breed can be found in the text above.

Order details
Test number8689
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration5-7 working days
Test specifications
Symptom complexhematologic
Causalitycausally
GeneF8
MutationG-C
LiteratureOMIA:000437-9615

Haemophilia A - German Shepherd Dog

The symptoms described in this breed can be found in the text above.

Order details
Test number8689
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration5-7 working days
Test specifications
Symptom complexhematologic
Causalitycausally
GeneF8
MutationC-T
LiteratureOMIA:000437-9615

Haemophilia A - Labrador Retriever

The symptoms described in this breed can be found in the text above.

Order details
Test number8689
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration5-7 working days
Test specifications
Symptom complexhematologic
Causalitycausally
GeneF8
MutationDEL
LiteratureOMIA:000437-9615

Haemophilia A - Old English Sheepdog

The symptoms described in this breed can be found in the text above.

Order details
Test number8689
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration5-7 working days
Test specifications
Symptom complexhematologic
Causalitycausally
GeneF8
MutationG-A
LiteratureOMIA:000437-9615

Haemophilia A - Rhodesian Ridgeback

The symptoms described in this breed can be found in the text above.

Order details
Test number8689
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration5-7 working days
Test specifications
Symptom complexhematologic
Causalitycausally
GeneF8
MutationINS
LiteratureOMIA:000437-9615