Epidermolytic hyperkeratosis (EHK)
Epidermolytic hyperkeratosis (EHK)
General description
This disease is caused by a keratin defect which leads to superficial, mild, plantar epidermolytic hyperkeratosis with epidermal fragility. Affected dogs show clinical signs from birth through adulthood. In adults clinical lesions become hyperpigmented and remain static.
Breeds
Norfolk Terrier
Order details
| Test number | 8311 |
| Abbreviation | EHK |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | dermatologic |
| Age of onset | very variable (from birth to old age) |
| Causality | causally |
| Gene | KRT10 |
| Mutation | G-T |
| Literature | OMIA:001415-9615 |
Detailed description
This disease is caused by a mutation in the KRT10 gene. The keratin defect leads to superficial, mild, plantar epidermolytic hyperkeratosis with epidermal fragility. Affected dogs show clinical signs from birth through adulthood. In adults clinical lesions become hyperpigmented and remain static.
