Nemalin myopathy (NM)
Nemalin myopathy (NM)
General description
Nemaline myopathy (NM) in American Bulldogs is an inherited disease characterised by muscular disorders such as muscle weakness, hypotonia, hypoventilation and swallowing dysfunction.
Breeds
American Bulldog
Order details
| Test number | 8172 |
| Abbreviation | NM |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | muscular |
| Inheritance | autosomal recessive |
| Causality | causally |
| Gene | NEB |
| Mutation | G-T |
| Literature | OMIA:002137-9615 |
Detailed description
Nemaline myopathy (NM) in American Bulldogs is an inherited disease caused by a recessive mutation in the NEB-gene. Affected dogs exhibit muscular disorders such as muscle weakness, hypotonia, hypoventilation and swallowing dysfunction. Typically, thread-like rod formations called nemaline bodies can be found in skeletal muscle fibers.
