Dandy-Walker-like malformation (DWLM)
Dandy-Walker-like malformation (DWLM)
General description
DWLM as a disease is caused by a malformation of the cerebellum. Symptoms include various forms of ataxia and commence at the age of 5-6 weeks. Affected dogs exhibit wobbly gait, loss of balance or periodic reoccurring collapses. Epileptic seizures were described in some cases as well.
Breeds
Eurasian
Order details
| Test number | 8260 |
| Abbreviation | DWLM |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | neurological |
| Inheritance | autosomal recessive |
| Age of onset | 5-6 weeks |
| Causality | causally |
| Gene | VLDLR |
| Mutation | DEL |
| Literature | OMIA:001947-9615 |
Detailed description
Workgroups of Prof. Andrea Fischer from the university of Munich and of Prof. Tosso Leeb from the university of Bern found a causative mutation for cerebellar hypoplasia in dogs for the first time: A mutation in the VLDLR-gene is responsible for the so called Dandy-Walker-like malformation (DWLM) found in Eurasian dogs. DWLM as a disease is caused by a malformation of the cerebellum. Symptoms include various forms of ataxia and commence at the age of 5-6 weeks. Affected dogs exhibit wobbly gait, loss of balance or periodic reoccurring collapses. Epileptic seizures were described in some cases as well.
