Hereditary neuropathy (GHN)

General description

Clinical symptoms include progressive amyosthenia, exercise intolerance, loss of reflexes and ataxia of all limbs. When palsy affects the larynx, changes in voice and problems in swallowing and regurgitating have also been described. The general condition is not influenced by the disease.

Breeds

Greyhound

Order details
Test number8179
AbbreviationGHN
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration5-7 working days
Test specifications
Symptom complexneurological
Inheritanceautosomal recessive
Age of onset0-2 years
Causalitycausally
GeneNDRG1
MutationDEL
LiteratureOMIA:002120-9615
Detailed description

Hereditary polyneuropathy causes undersupply of the peripheric nervous system followed by nerve degeneration. Due to the lack of nervous stimulation the muscles degrade gradually. The onset of clinical symptoms occurs during the first two years of a dog´s life. These symptoms include progressive amyosthenia, exercise intolerance, loss of reflexes and ataxia of all limbs. So, the dog may fall down, walk on the tops of his feet or his gait may just look a little off. When palsy affects the larynx, changes in voice and problems in swallowing and regurgitating have also been described. The general condition is not influenced by the disease. There are some other spinal or neurological problems that may cause similar symptoms, so it may often be misdiagnosed or undiagnosed.