Hypomyelinisierung
Hypomyelination/Shaking puppy syndrome (SPS)
General description
The disease is caused by disruption of myelination in the spinal cord. Affected dogs show a generalized tremor at age of 12 to 14 days.
Breeds
English Springer Spaniel, Weimaraner
Detailed description
The disease is caused by disruption of myelination in the spinal cord. Affected dogs show a generalized tremor at age of 12 to 14 days. The severity of thremor can vary between litter mates. The dogs can ambulate, but show a “hopping” gait in the hind limbs. The tremor is not present when the dogs are at rest or asleep and diminishes over time by 3 to 4 months of age.
Hypomyelination - English Springer Spaniel
The symptoms described in this breed can be found in the text above.
Order details
| Test number | 8443 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | neuromuscular |
| Age of onset | 2 weeks |
| Causality | causally |
| Gene | PLP1 |
| Mutation | A-C |
| Literature | OMIA:000770-9615 |
Hypomyelination - Weimaraner
The symptoms described in this breed can be found in the text above.
Order details
| Test number | 8443 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | neuromuscular |
| Causality | causally |
| Gene | FNIP2 |
| Mutation | DEL |
| Literature | OMIA:000526-9615 |
