H-locus (harlequin)
H-locus (harlequin)
General description
The H-locus in conjunction with the M-locus causes an unregular black and white pattern called harlequin in Great Danes.
Breeds
Great Dane
Order details
| Test number | 8254 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Inheritance | Allelic series: H dominant over h |
| Gene | PSMB7 |
| Mutation | T-G |
| Literature | OMIA:001454-9615 |
Detailed description
Harlequin is a typical coat colour of Great Danes, which show black patterns on white background. This characteristic is caused by a modifier-gene for the M-locus. The dominant H-allele changes the Merle pattern to harlequin. Therefore, the genotype N/M at the M-locus is needed in addition to H/h. The dominant H-allele is lethal when found homozygous (H/H). Affected puppies die before birth.
