Persistent Müllerian duct syndrome (PMDS)
Persistent Müllerian duct syndrome (PMDS)
General description
The persistent Mullerian duct syndrome (PMDS) is characterised by an incomplete regression of the Mullerian duct during sex- differentiation in the male dog. Therefore, underdeveloped female internal genitals like the uterus can be found in affected dogs. Further symptoms include undescended testes, infertility and sometimes tumors.
Breeds
Miniature Schnauzer
Order details
| Test number | 8462 |
| Abbreviation | PMDS |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | urological |
| Inheritance | autosomal recessive |
| Age of onset | from birth |
| Causality | causally |
| Gene | AMHR2 |
| Mutation | G-A |
| Literature | OMIA:002775-9615 |
Detailed description
The persistent Mullerian duct syndrome (PMDS) is caused by a Mutation in the MISRII-gene. Due to an incomplete regression of the Mullerian duct during sex- differentiation in the male dog, underdeveloped female internal genitals like the uterus can be found in affected dogs. Further symptoms include undescended testes, infertility and sometimes tumors. Normally, external genitilia are fully developed.
