Glanzmann Thrombasthenie (GT)
Glanzmann thrombasthenia (GT)
General description
Glanzmann’s Thrombasthenia is a bleeding disorder that occurs in two different types. Symptomatically GT shows in form of bleeding diathesis and continuous gingival bleeding after shedding of deciduous teeth. Continuous epistaxis can also be an indication for this disorder.
Breeds
Pyrenean Mountain Dog
Order details
| Test number | 8077 |
| Abbreviation | GT |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | hematologic |
| Inheritance | autosomal recessive |
| Causality | causally |
| Gene | ITGA2B |
| Mutation | DEL |
| Literature | OMIA:001000-9615 |
Detailed description
Glanzmann’s thrombasthenia is a bleeding disorder that occurs in two different types. They differ in the amount of specific glycoproteins (aIIbb3) embedded in the cell membrane of platelets (thrombocytes), which are important part of the coagulation system. In the severe GT of type I this amount of glycoprotein is less than 5% of the normal value. A mutation in the aIIb gene disrupts the production of one main component of these glycoproteins. Symptomatically GT shows in form of bleeding diathesis and continuous gingival bleeding after shedding of deciduous teeth. Continuous epistaxis can also be an indication for this disorder.
