Paroxysmale Dyskinesie (PxD)
Paroxysomal dyskinesia (PxD)
General description
Breeds
Irish Soft Coated Wheaten Terrier
Order details
| Test number | 8630 |
| Abbreviation | PxD |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | neurological |
| Inheritance | autosomal recessive |
| Age of onset | 2 years |
| Causality | causally |
| Gene | PIGN |
| Mutation | C-T |
| Literature | OMIA:002084-9615 |
Detailed description
Hereditary paroxysmal dyskinesia (PxD) are heterogenous movement disorders. In Irish Soft-Coated Wheaten Terriers, a young-adult onset PxD form segregates as an autosomal-recessive trait. Affected dogs suffer from episodes of sudden, automatic and unpredictable movements of the hindlimbs (and sometimes forelimbs), known as hyperkinesia. These attacks last several minutes to hours and occur about 10 times a day. First symptoms occur at the age of about two years and worsen with age.
