Postoperative Blutungsneigung (DEPOH) – Deerhound, Greyhound, Magyar Agar
Delayed postoperative hemorrhage (DEPOH) - Deerhound, Greyhound, Hungarian Greyhound*
General description
A variant in the SERPINF2 gene in the breeds Scottish Deerhound, Greyhound and Hungarian Greyhound is associated with an increased risk of developing delayed postoperative hemorrhage (DEPOH).
Breeds
Deerhound, Greyhound, Hungarian Greyhound (Magyar agár)
Order details
| Test number | 9134 |
| Abbreviation | DEPOH |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | hematologic |
| Inheritance | autosomal dominant with incomplete penetrance |
| Causality | High-risk factor |
| Gene | SERPINF2 |
| Mutation | C-T |
| Literature | OMIA:002631-9615 |
Detailed description
A variant in the SERPINF2 gene has been identified in the breeds Scottish Deerhound, Greyhound and Hungarian Greyhound that is associated with an increased risk of developing delayed postoperative hemorrhage (DEPOH).
Clinical signs are the unexpected, excessive bleeding or bruising starting 1 to 4 days after a surgical procedure. The symptoms vary from frank bleeding from the wound, to excessive and also progressive bruising of the skin surrounding the wound and hemoabdomen.
The results of coagulation screening tests like the measurements of prothrombin time, activated partial thromboplastin time and von Willebrand factor antigen, as well as platelet counts were unremarkable.
Compared to dogs not carrying the marker variant, dogs with two variant alleles as well as dogs with one variant allele show an increased risk of developing DEPOH.
