Fanconi syndrome
Fanconi syndrome
General description
Due to renal dysfunction, electrolytes and nutritive substances can not be reabsorbed from the urine in Fanconi affected dogs. Therefore, important metabolic substrates are excreted with the urine and excessive uptake of water and urinating are typical symptoms. Without treatment, affected dogs exhibit amyosthenia, acidosis and general weakness that leads to death ultimately.
Breeds
Basenji
Order details
| Test number | 8272 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | nephrological |
| Inheritance | autosomal recessive |
| Age of onset | 4-8 years |
| Causality | causally |
| Gene | FAN1 |
| Mutation | COMPLEX |
| Literature | OMIA:002683-9615 |
Detailed description
Fanconi syndrome is an inherited disease in the Basenji. Due to renal dysfunction, electrolytes and nutritive substances can not be reabsorbed from the urine. Therefore, important metabolic substrates are excreted with the urine. Excessive uptake of water and urinating are typical symptoms. High glucose concentrations can be measured in the urine as well. Without treatment, affected dogs exhibit amyosthenia, acidosis and general weakness that leads to death ultimately. In Basenji dogs onset of Fanconi syndrome is found at the age of four to eight years.
