Amelogenesis imperfecta (AI)(Familial enamel hypoplasia)

General description

Amelogenesis imperfecta (AI) or Familial enamel hypoplasie is associated with tooth enamel malformation due to disruption of Enamelin production. Affected animals have slim, pointed teeth with thin brown tooth enamel.

Breeds

Akita, American Akita, Italian Sighthound, Parson Russell Terrier, Samoyed

Detailed description

Amelogenesis imperfecta or familial enamel hypoplasia (FEH) is an inherited condition of tooth enamel malformation. It is caused by a mutation in the ENAM or ACP4 gene which disrupts the production of Enamelin, an important component of tooth enamel. Affected animals have slim, pointed teeth with thin brown tooth enamel. Despite this condition the teeth do not seem to be more susceptible for dental cavities.

Amelogenesis imperfecta (AI) - Akita

The symptoms described in this breed can be found in the text above.

Order details

Test number	8303
Sample material	0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration	7-14 working days

Test specifications

Symptom complex	dental
Inheritance	autosomal recessive
Causality	causally
Gene	ACP4
Mutation	INS
Literature	OMIA:002177-9615

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Amelogenesis imperfecta (AI) - Italian Sighthound

The symptoms described in this breed can be found in the text above.

Order details

Test number	8303
Sample material	0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration	7-14 working days

Test specifications

Symptom complex	dental
Inheritance	autosomal recessive
Causality	causally
Gene	ENAM
Mutation	DEL
Literature	OMIA:001805-9615

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Amelogenesis imperfecta (AI) - Parson Russell Terrier

The symptoms described in this breed can be found in the text above.

Order details

Test number	8303
Sample material	0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration	7-14 working days

Test specifications

Symptom complex	dental
Inheritance	autosomal recessive
Causality	causally
Gene	ENAM
Mutation	C-T
Literature	OMIA:001805-9615

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Amelogenesis imperfecta (AI) - Samoyed

The symptoms described in this breed can be found in the text above.

Order details

Test number	8303
Sample material	0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration	7-14 working days

Test specifications

Symptom complex	dental
Inheritance	autosomal recessive
Causality	causally
Gene	SLC24A4
Mutation	INS
Literature	OMIA:001805-9615

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