Trapped neutrophil syndrome (TNS)
Trapped neutrophil syndrome (TNS)
General description
In Trapped neutrophil syndrome (TNS) affected dogs, neutrophils are produced by the bone marrow, but lack the ability to reach the blood stream. Therefore, affected puppies posses a weak immune system and show variable symptoms depending on respective infection. Most of the affected dogs die before the fifth month of their live.
Breeds
Border Collie
Order details
| Test number | 8143 |
| Abbreviation | TNS |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3-5 working days |
Test specifications
| Symptom complex | immunological |
| Inheritance | autosomal recessive |
| Causality | causally |
| Gene | VPS13B |
| Mutation | DEL |
| Literature | OMIA:001428-9615 |
Detailed description
In TNS affected dogs, neutrophils are produced by the bone marrow, but lack the ability to reach the blood stream. Therefore, affected puppies posses a weak immune system and are not able to fight pathogens effectively. The variable symptoms observed depend on the respective infection. Equally, starting point and severity of the TNS-disease vary, with most of the dogs dying before the fifth month of their live. In rare cases, dogs can live a normal life due to antibiotic- and steroid-therapies.
