Haemophilia B (Factor IX deficiency)

General description

The underlying pathomechanism of haemophilia B is a lack or decreased activity of factor IX that plays a critical role in the coagulation cascade. The clinical signs include haematomas of large sizes, bleeding of the nose, skin, muscles and joints. If the disease is severe and no precautions are taken, affected dogs can bleed to death after surgery or injuries.

Breeds

American Akita, Hovawart, Lhasa Apso, Rhodesian Ridgeback

Detailed description

Haemophilia B is one of the most important inherited disorders of haemostasis in Rhodesian Ridgeback Dogs. The underlying pathomechanism of haemophilia B is a lack or decreased activity of factor IX that plays a critical role in the coagulation cascade. Affected dogs present with hemorrhage that can vary from mild to severe depending on the degree of the disease. The clinical signs include haematomas of large sizes, bleeding of the nose, skin, muscles and joints. If the disease is severe and no precautions are taken, affected dogs can bleed to death after surgery or injuries. Genetic causes for Haemophilia B have been described for some cases in the breeds American Akita, Hovawart and Lhasa Apso as well.

Hemophilia B - American Akita

The symptoms described in this breed can be found in the text above.

Order details
Test number8221
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration3-5 working days
Test specifications
Symptom complexhematologic
InheritanceX-chromosomal recessive
Causalitycausally
GeneF9
MutationT-C

Hemophilia B - Hovawart

The symptoms described in this breed can be found in the text above.

Order details
Test number8221
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration3-5 working days
Test specifications
Symptom complexhematologic
InheritanceX-chromosomal recessive
Causalitycausally
GeneF9
MutationDEL
LiteratureOMIA:000438-9615

Hemophilia B - Lhasa Apso

The symptoms described in this breed can be found in the text above.

Order details
Test number8221
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration3-5 working days
Test specifications
Symptom complexhematologic
InheritanceX-chromosomal recessive
Causalitycausally
GeneF9
MutationCOMPLEX
LiteratureOMIA:000438-9615

Hemophilia B - Rhodesian Ridgeback

The symptoms described in this breed can be found in the text above.

Order details
Test number8221
Sample material0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)
Test duration3-5 working days
Test specifications
Symptom complexhematologic
InheritanceX-chromosomal recessive
Causalitycausally
GeneF9
MutationG-A
LiteratureOMIA:000438-9615