Canine multi-focal retinopathy (CMR1/2/3)
Canine multi-focal retinopathy (CMR)
General description
Canine multifocal retinopathy (CMR) is a slow progressive disease associated with multiple lesions of the retina. First symptoms can be found at the age of about four month. Im some cases lesions disappear for some time and emerge again later on. Blindness or visual impairment was not found in affected dogs yet.
Breeds
American Bulldog, Australian Shepherd, Boerboel, Bullmastiff, Coton de Tuléar, Dogue de Bordeaux, English Bulldog, Finnish Lapponian Dog, French Bulldog, Italian Cane Corso, Lapponian Herder, Mastiff, Miniature American Shepherd, Presa Canario, Pyrenean Mountain Dog, Swedish Lapphund
Detailed description
Canine multifocal retinopathy (CMR) is an inherited disease which causes lesions of the retina. The distinct course of the disease is not fully known yet and varies in the affected breeds. First symptoms can be found at the age of about four month. The progression of the disease is slow. In some cases, lesions disappear for some time and emerge again later on. Research about the pathology of the CMR is still to be done to investigate the stages of the disease completely. Blindness or visual impairment was not found in affected dogs yet.
Canine Multi-Focal Retinopathy CMR1
The symptoms described in this breed can be found in the text above.
Order details
| Test number | 8330 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3 - 5 working days (CMR1 and CMR2), 7-14 working days (CMR3) |
Test specifications
| Symptom complex | ophthalmic |
| Inheritance | autosomal recessive |
| Age of onset | 4 months |
| Causality | causally |
| Gene | BEST1 |
| Mutation | G-A |
| Literature | OMIA:001444-9615 |
Canine Multi-Focal Retinopathy CMR2
The symptoms described in this breed can be found in the text above.
Order details
| Test number | 8330 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3 - 5 working days (CMR1 and CMR2), 7-14 working days (CMR3) |
Test specifications
| Symptom complex | ophthalmic |
| Inheritance | autosomal recessive |
| Age of onset | 4 months |
| Causality | causally |
| Gene | BEST1 |
| Mutation | C-T |
| Literature | OMIA:001553-9615 |
Canine Multi-Focal Retinopathy CMR3
The symptoms described in this breed can be found in the text above.
Order details
| Test number | 8330 |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 3 - 5 working days (CMR1 and CMR2), 7-14 working days (CMR3) |
Test specifications
| Symptom complex | ophthalmic |
| Inheritance | autosomal recessive |
| Age of onset | 4 months |
| Causality | causally |
| Gene | BEST1 |
| Mutation | DEL |
| Literature | OMIA:001554-9615 |
