{"id":282916,"date":"2025-08-06T10:10:57","date_gmt":"2025-08-06T08:10:57","guid":{"rendered":"https:\/\/labogen.com\/?page_id=282916"},"modified":"2025-08-06T10:10:58","modified_gmt":"2025-08-06T08:10:58","slug":"polioenzephalopathie-pe","status":"publish","type":"page","link":"https:\/\/labogen.com\/uk\/erbkrankheiten-hund\/polioenzephalopathie-pe\/","title":{"rendered":"Polioenzephalopathie (PE)"},"content":{"rendered":"

Polioencephalopathy (PE)<\/h1>

General description<\/strong><\/h4>

In a Eurasier family, a form of polioencephalopathy was linked to a genetic variant in the MECR gene. The affected puppies began to show movement disorder episodes between the ages of 2 and 6 months with increasing frequency and severity. As the disease progressed, further motor impairments developed, and in some dogs also divergent strabismus. <\/p>

Breeds<\/span><\/strong><\/h4>

Eurasian<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8965<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Polioencephalopathy (PE)<\/strong> is a neurological disorder<\/strong> characterized by lesions in the grey matter of the brain. It occurs in humans and, more rarely, in animals, and is typically a consequence of metabolic disturbances such as malnutrition, toxicity, or congenital metabolic defects. This condition can lead to a wide range of neurological impairments. Because the clinical signs of PE can be very diverse, diagnosing the disease based on symptoms alone is challenging.<\/p>

In a Eurasier family<\/strong>, a form of polioencephalopathy was linked to a genetic variant in the MECR <\/em>gene<\/strong>. The affected puppies began to show movement disorder episodes<\/strong> between the ages of 2 and 6 months<\/strong>. These included generalized ataxia, a hypermetric gait (exaggerated limb movements), dystonia (muscle spasms), and uncontrolled flexion and extension movements of the forelimbs. The frequency and severity of these episodes increased over time<\/strong>. Additionally, there were indications that excitement, loud noises, or overstimulation may trigger the episodes.<\/p>

As the disease progressed, further motoric impairments <\/strong>developed, including difficulties with walking and standing, muscle atrophy, and abnormal posture. Some dogs also showed divergent strabismus<\/strong> (eyes pointing outward). However, no impairments in consciousness or behaviour were observed.<\/p>

The MECR <\/em>gene encodes the mitochondrial enzyme trans-2-enoyl-CoA reductase, which plays a key role in lipoic acid synthesis. Lipoic acid is essential for mitochondrial fatty acid synthesis and energy metabolism. Variants in the MECR gene lead to neurodegenerative changes, particularly in energy-demanding tissues such as the basal ganglia in the brain and the optic nerve.<\/p><\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":15,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-282916","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/282916","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/comments?post=282916"}],"version-history":[{"count":1,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/282916\/revisions"}],"predecessor-version":[{"id":282917,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/282916\/revisions\/282917"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/media?parent=282916"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}