{"id":274694,"date":"2024-09-12T07:24:02","date_gmt":"2024-09-12T05:24:02","guid":{"rendered":""},"modified":"2024-09-12T07:24:02","modified_gmt":"2024-09-12T05:24:02","slug":"combination-cocker-spaniel","status":"publish","type":"page","link":"https:\/\/labogen.com\/uk\/%d0%bf%d0%b0%d0%ba%d0%b5%d1%82%d0%b8-%d0%ba%d0%be%d0%bc%d0%b1%d1%96%d0%bd%d0%b0%d1%86%d1%96%d1%97-%d1%82%d0%b5%d1%81%d1%82%d1%96%d0%b2-%d1%81%d0%be%d0%b1%d0%b0%d0%ba%d0%b0\/combination-cocker-spaniel\/","title":{"rendered":"Combination Cocker Spaniel"},"content":{"rendered":"

Combination Cocker Spaniel<\/h1>

General description<\/strong><\/h4>

includes: Acral mutilation syndrome (AMS), Familial nephropathy (FN), Progressive retinal atrophy (prcd-PRA)<\/p>

Breeds<\/span><\/strong><\/h4>

American Cocker Spaniel, English Cocker Spaniel<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8662<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>3-5 working days<\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Acral mutilation syndrome - English Cocker Spaniel, English Pointer, English Springer Spaniel, French Spaniel, German Shorthaired Pointer<\/h4>

In breeds such as German Shorthaired Pointer, English Pointer, English Cocker Spaniel, English Springer Spaniel, and French Spaniel,<\/strong> symptoms typically appear around four months of age<\/strong>, when puppies begin licking, biting, or injuring their paws and toes. Despite this, proprioception, motor function, and spinal reflexes remain unaffected. Some affected puppies only show pain insensitivity in the lower limbs without self-injury, making diagnosis more challenging.<\/p><\/p><\/div>

Test specifications<\/summary>
Symptom complex<\/strong><\/td>neurological<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>4 months <\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>GDNF<\/td><\/tr>
Mutation<\/strong><\/td>C-T<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001514-9615<\/a><\/td><\/tr><\/table><\/details><\/div><\/div><\/div>
<\/div><\/div>

Progressive retinal atrophy (prcd-PRA)<\/h4><\/div>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>ophthalmic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>PRCD<\/td><\/tr>
Mutation<\/strong><\/td>C-T<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001298-9615<\/a><\/td><\/tr><\/table><\/details><\/div><\/div><\/div>
<\/div><\/div>

Familial nephropathy (FN) - English Cocker Spaniel, Welsh Springer Spaniel <\/h4><\/div>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>nephrological<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>6 months- 2 years <\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>COL4A4<\/td><\/tr>
Mutation<\/strong><\/td>T-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002618-9615<\/a><\/td><\/tr><\/table><\/details><\/div><\/div><\/div>
<\/div><\/div>
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