{"id":274565,"date":"2024-09-12T07:24:02","date_gmt":"2024-09-12T05:24:02","guid":{"rendered":""},"modified":"2024-09-12T07:24:02","modified_gmt":"2024-09-12T05:24:02","slug":"combination-american-staffordshire-terrier","status":"publish","type":"page","link":"https:\/\/labogen.com\/uk\/%d0%bf%d0%b0%d0%ba%d0%b5%d1%82%d0%b8-%d0%ba%d0%be%d0%bc%d0%b1%d1%96%d0%bd%d0%b0%d1%86%d1%96%d1%97-%d1%82%d0%b5%d1%81%d1%82%d1%96%d0%b2-%d1%81%d0%be%d0%b1%d0%b0%d0%ba%d0%b0\/combination-american-staffordshire-terrier\/","title":{"rendered":"Combination American Staffordshire Terrier"},"content":{"rendered":"

Combination American Staffordshire Terrier<\/h1>

General description<\/strong><\/h4>

includes (15 Euro patent fee for DM Exon2): Degenerative myelopathy (DM exon 2), Neuronal ceroid lipofuscinosis (NCL), Progressive retinal atrophy (crd1-PRA), D-Locus d1 (Dilution)<\/p>

Breeds<\/span><\/strong><\/h4>

American Staffordshire Terrier<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8832<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

D-locus d1 (dilution)<\/h4><\/div>
Test specifications<\/summary>
Inheritance<\/strong><\/td>Allelic series: D dominant over d1, d2 and d3<\/td><\/tr>
Gene<\/strong><\/td>MLPH<\/td><\/tr>
Mutation<\/strong><\/td>G-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000031-9615<\/a><\/td><\/tr><\/table><\/details><\/div><\/div><\/div>
<\/div><\/div>

Degenerative myelopathy exon 2 (DM exon 2)<\/h4><\/div>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>neuromuscular<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive with age-dependent incomplete penetrance; a risk factor associated with DM is detected.<\/td><\/tr>
Age of onset<\/strong><\/td>from 8 years<\/td><\/tr>
Causality<\/strong><\/td>High-risk factor<\/td><\/tr>
Gene<\/strong><\/td>SOD1<\/td><\/tr>
Mutation<\/strong><\/td>G-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000263-9615<\/a><\/td><\/tr><\/table><\/details><\/div><\/div><\/div>
<\/div><\/div>

Progressive retinal atrophy (crd1-PRA)<\/h4><\/div>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>ophthalmic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>6 months <\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>PDE6B<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001674-9615<\/a><\/td><\/tr><\/table><\/details><\/div><\/div><\/div>
<\/div><\/div>

Neuronal ceroid lipifuscinosis (NCL) - American Staffordshire Terrier<\/h4><\/div>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>neurological<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>ARSG<\/td><\/tr>
Mutation<\/strong><\/td>G-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001503-9615<\/a><\/td><\/tr><\/table><\/details><\/div><\/div><\/div>
<\/div><\/div>
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