{"id":238854,"date":"2024-09-12T07:23:52","date_gmt":"2024-09-12T05:23:52","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/skelettatavismus-sa"},"modified":"2024-09-12T07:23:52","modified_gmt":"2024-09-12T05:23:52","slug":"skelettatavismus-sa","status":"publish","type":"page","link":"https:\/\/labogen.com\/uk\/erbkrankheiten-pferd\/skelettatavismus-sa\/","title":{"rendered":"Skelettatavismus (SA)"},"content":{"rendered":"

Skeletal atavism (SA)*<\/h1>

General description<\/strong><\/h4>

Skeletal atavism, an inherited bone development disorder found in Miniature Horses and Shetland Ponies, is characterized by severe angle anomalies and deformation of the front knee and hock. Affected horses typically display short legs, clubfootedness, and impaired movement.<\/p>

Breeds<\/span><\/strong><\/h4>

American Miniature Horse, Shetland pony<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8854<\/td><\/tr>
Abbreviation<\/strong><\/td>SA<\/td><\/tr>
Sample material<\/strong><\/td>mane\/tail hair roots<\/td><\/tr>
Test duration<\/strong><\/td>21-28 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>skeletal<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002013-9796<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Skeletal atavism is a heritable defect of bone development that occurs in Shetland Ponies and American Miniature Horses. It is characterized by the ulna (bone next to radius) and fibula (bone next to tibia) growing too long and failing to fuse to the radius and tibia, leading to abnormal limb development. The defect affects both front and hind limbs, resulting in severe angle anomalies and deformation of the front knee and hock. Horses with skeletal atavism typically display short legs, a low rectangular shape body, narrowing at the knees, clubfoot, and impaired movement. The angles of the legs and pattern of movement progressively worsen as the foal ages, and in most cases, the horse has to be euthanized within six months. A team of researchers in Sweden identified two independent, overlapping regions in the SHOX gene where DNA sequences were lost (deletions) in affected ponies. The deletions (Del1 and Del2) are of different sizes with the larger deletion (Del1) being more common among ponies. It is estimated that about 12% of Shetland ponies are carriers.<\/p><\/details><\/div>

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