{"id":218870,"date":"2024-09-12T07:23:51","date_gmt":"2024-09-12T05:23:51","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/methaemoglobinaemie-methg"},"modified":"2024-09-12T07:23:51","modified_gmt":"2024-09-12T05:23:51","slug":"methaemoglobinaemie-methg","status":"publish","type":"page","link":"https:\/\/labogen.com\/uk\/erbkrankheiten-hund\/methaemoglobinaemie-methg\/","title":{"rendered":"Meth\u00e4moglobin\u00e4mie (MetHg)"},"content":{"rendered":"

Methaemoglobinaemia (MetHg)<\/h1>

General description<\/strong><\/h4>

A variant in the CYB5R3 gene was found in Pomeranians to cause Methemoglobinemia (MetHg). Methemoglobinemia is characterized as in increase in the concentration of oxidized hemoglobin in the blood. Methemoglobin impairs the normal transport of oxygen to tissues, leading to cyanosis and exercise intolerance. Physical examination of affected dogs showed a bluish discoloration of dog\u2019s oral mucous membranes, tongue, and lower abdominal skin.<\/p>

Breeds<\/span><\/strong><\/h4>

Pomeranian, Pomsky<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8870<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>haematologic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Gene<\/strong><\/td>CYB5R3<\/td><\/tr>
Mutation<\/strong><\/td>A-C<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002131-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

A variant in the CYB5R3 gene was found in Pomeranians to cause methemoglobinemia (MetHg). Methemoglobinemia is characterized as increase in the concentration of oxidized hemoglobin in the blood. Methemoglobin impairs the normal transport of oxygen to tissues, leading to cyanosis and exercise intolerance. Physical examination of affected dogs showed a bluish discoloration of dog\u2019s oral mucous membranes, tongue, and lower abdominal skin, while no cardiac or pulmonary abnormalities were detected on auscultation. Blood examinations showed a notably lower b5R (NADH-cytochrome b5 reductase) level and the colour of the blood was much darker red to brownish compared to healthy dogs. During surgery, one affected dog\u2019s percutaneous oxygen saturation fell to 90% (reference range, 96\u2013100%), which could not be explained by surgical or anaesthetic complications.<\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218870","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/218870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/comments?post=218870"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/218870\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/media?parent=218870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}