{"id":218862,"date":"2024-09-12T07:23:51","date_gmt":"2024-09-12T05:23:51","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/postoperative-blutungsneigung-depoh-deerhound-greyhound"},"modified":"2025-11-13T11:23:36","modified_gmt":"2025-11-13T10:23:36","slug":"postoperative-blutungsneigung-depoh-deerhound-greyhound","status":"publish","type":"page","link":"https:\/\/labogen.com\/uk\/erbkrankheiten-hund\/postoperative-blutungsneigung-depoh-deerhound-greyhound\/","title":{"rendered":"Postoperative Blutungsneigung (DEPOH) \u2013 Deerhound, Greyhound, English Springer Spaniel, Magyar Agar, Welsh Springer Spaniel"},"content":{"rendered":"

Delayed postoperative hemorrhage (DEPOH) - English Springer Spaniel, Welsh Springer Spaniel <\/h1>

General description<\/strong><\/h4>

In the breeds English Springer Spaniel (ESS) and Welsh Springer Spaniel (WSS), a genetic variant in the SERPINE1 gene has been identified that can lead to a postoperative bleeding tendency with hyperfibrinolysis.<\/p>

Breeds<\/span><\/strong><\/h4>

Deerhound, English Springer Spaniel, Greyhound, Hungarian Greyhound (Magyar ag\u00e1r), Welsh Springer Spaniel<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8862<\/td><\/tr>
Abbreviation<\/strong><\/td>DEPOH<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>hematologic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>High-risk factor<\/td><\/tr>
Gene<\/strong><\/td>SERPINF2<\/td><\/tr>
Mutation<\/strong><\/td>C-T<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002631-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
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Detailed description<\/summary>

In the breeds English Springer Spaniel (ESS) and Welsh Springer Spaniel (WSS)<\/strong>, a genetic variant in the SERPINE1<\/em> gene<\/strong> has been identified that can lead to a postoperative bleeding tendency with hyperfibrinolysis<\/strong>.<\/p>

Hyperfibrinolysis<\/strong> refers to a disorder of the blood clotting system in which formed blood clots dissolve too quickly. Normally, fibrinolysis ensures that a blood clot is gradually broken down after wound healing is complete. In hyperfibrinolysis, however, this breakdown process occurs far too early and too intensely. As a result, blood clots can no longer permanently seal the bleeding site, leading to persistent or delayed bleeding.<\/strong><\/p>

In affected dogs of these two breeds, the disease often becomes apparent at a young age (from around 7 months)<\/strong>, often after surgical procedures or trauma. In addition to delayed and prolonged bleeding after surgery, affected dogs may also suffer from spontaneous bleeding into the abdominal cavity or subcutaneous tissue<\/strong>, as well as hematomas or bloody wound secretions<\/strong>. The affected dogs may appear weak and lethargic, with pale gums and a low pulse.<\/p>

Standard coagulation tests (PT, PTT, buccal mucosal bleeding time) are usually within normal ranges, which makes it difficult to identify hyperfibrinolysis as the underlying cause of bleeding without genetic testing.<\/p>

The SERPINE1<\/em> gene encodes the protein plasminogen activator inhibitor-1 (PAI-1), which normally regulates the breakdown of blood clots. Due to the genetic variant, no functional PAI-1 is produced in the platelets, which can result in life-threatening bleeding<\/strong>.<\/p>

Since heterozygous dogs were still found to produce detectable PAI-1 protein and no increased bleeding tendency has been reported in these animals, the inheritance pattern is assumed to be autosomal recessive.<\/strong><\/p><\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218862","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/218862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/comments?post=218862"}],"version-history":[{"count":3,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/218862\/revisions"}],"predecessor-version":[{"id":285130,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/218862\/revisions\/285130"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/media?parent=218862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}