{"id":218475,"date":"2024-09-12T07:23:50","date_gmt":"2024-09-12T05:23:50","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/imerslund-graesbeck-syndrom-igs"},"modified":"2024-09-12T07:23:50","modified_gmt":"2024-09-12T05:23:50","slug":"imerslund-graesbeck-syndrom-igs","status":"publish","type":"page","link":"https:\/\/labogen.com\/uk\/erbkrankheiten-hund\/imerslund-graesbeck-syndrom-igs\/","title":{"rendered":"Imerslund-Gr\u00e4sbeck Syndrom (IGS)"},"content":{"rendered":"

Imerslund-Gr\u00e4sbeck syndrome (IGS)<\/h1>

General description<\/strong><\/h4>

Imerslund-Gr\u00e4sbeck Syndrome (IGS) is characterised by malabsorption of Vitamin B12. Lack of cobalamin leads ultimately to irreversible damage of the brain and nervous system. IGS can be managed by supplementation with regular doses of cobalamin.<\/p>

Breeds<\/span><\/strong><\/h4>

Australian Shepherd, Beagle, Border Collie, Komondor, Miniature American Shepherd<\/p>

Detailed description<\/summary>

The Imerslund Gr\u00e4sbeck Syndrome (IGS)<\/strong> is an inherited disorder of vitamin B12 absorption<\/strong> (cobalamin malabsorption). Affected dogs are unable to absorb vitamin B12 (cobalamin) from the intestine into the bloodstream despite normal feeding. As a result, a chronic cobalamin deficiency develops, which impairs the blood-forming system and may lead to anaemia<\/strong> and neurological deficits<\/strong>. If left untreated, permanent (irreversible) damage to the brain and nervous system<\/strong> may occur.<\/p>

Clinical signs typically appear in early puppyhood, between approximately 6 and 12 weeks of age<\/strong>, when the body\u2019s cobalamin stores become depleted. Common signs include poor weight gain and growth retardation (failure to thrive), weight loss, lethargy, loss of appetite, anaemia<\/strong> and general weakness<\/strong>. In some cases, protein in the urine (proteinuria) is also detected.<\/p>

Imerslund Gr\u00e4sbeck Syndrome is not curable; however, with early diagnosis it can be effectively managed through consistent and lifelong vitamin B12 supplementation. With appropriate treatment, affected dogs can achieve a good quality of life.<\/p><\/p><\/details><\/div><\/div>

<\/div><\/div>

Imerslund-Gr\u00e4sbeck-Syndrome (IGS) -Australian Shepherd, Miniature American Shepherd<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8475<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>6-12 weeks<\/td><\/tr>
Gene<\/strong><\/td>AMN<\/td><\/tr>
Mutation<\/strong><\/td>G-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000565-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Imerslund-Gr\u00e4sbeck-Syndrome (IGS) - Beagle<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8475<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>6-12 weeks<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>CUBN<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001786-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Imerslund-Gr\u00e4sbeck-Syndrome (IGS) - Border Collie<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8475<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>6-12 weeks<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>CUBN<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001786-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Imerslund-Gr\u00e4sbeck-Syndrome (IGS) - Komondor<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8475<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>6-12 weeks<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>CUBN<\/td><\/tr>
Mutation<\/strong><\/td>G-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001786-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
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