{"id":218184,"date":"2024-09-12T07:23:48","date_gmt":"2024-09-12T05:23:48","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/c3-defizienz-c3"},"modified":"2024-09-12T07:23:48","modified_gmt":"2024-09-12T05:23:48","slug":"c3-defizienz-c3","status":"publish","type":"page","link":"https:\/\/labogen.com\/uk\/erbkrankheiten-hund\/c3-defizienz-c3\/","title":{"rendered":"C3-Defizienz (C3)"},"content":{"rendered":"<div class=\"wrap-top\"><div class=\"wrap-left\"><h1 class=\"header-1\">C3 deficiency (C3)<\/h1><h4><strong>General description<\/strong><\/h4><p class=\"bodytext\">The third component (C3) of the complement system plays an important role in the immune response to pathogens. Affected dogs exhibit higher susceptibility to  infections.<\/p><h4 class=\"header-4\"><strong><span>Breeds<\/span><\/strong><\/h4><p>Brittany Spaniel<\/p><\/div><div class=\"wrap-right\"><div class=\"wrap-toggle\"><div class=\"toggle-details\"><details><summary class=\"summary-details\">Order details<\/summary><table border=\"0\"><tr><td width=\"45%\"><span><strong>Test number<\/strong><\/span><\/td><td>8184<\/td><\/tr><tr><td><strong>Abbreviation<\/strong><\/td><td>C3<\/td><\/tr><tr><td><strong>Sample material<\/strong><\/td><td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr><tr><td><strong>Test duration<\/strong><\/td><td>7-14 working days<\/td><\/tr><\/table><\/details><details><summary class=\"summary-specs\">Test specifications<\/summary><table border=\"0\"><tr><td width=\"45%\"><strong>Symptom complex<\/strong><\/td><td>immunological<\/td><\/tr><tr><td width=\"45%\"><strong>Inheritance<\/strong><\/td><td>autosomal recessive<\/td><\/tr><tr><td width=\"45%\"><strong>Causality<\/strong><\/td><td>causally<\/td><\/tr><tr><td width=\"45%\"><strong>Gene<\/strong><\/td><td>C3<\/td><\/tr><tr><td width=\"45%\"><strong>Mutation<\/strong><\/td><td>DEL<\/td><\/tr><tr><td width=\"45%\"><strong>Literature<\/strong><\/td><td><a href='https:\/\/www.omia.org\/OMIA000155\/9615\/' target='_blank'>OMIA:000155-9615<\/a><\/td><\/tr><\/table><\/details><\/div><div class=\"order-now\"><strong><a href=\"https:\/\/shop.labogen.com\">Order now ...<\/a><\/strong><\/div><\/div><\/div><div class=\"clear-both\"><\/div><\/div><div class=\"wrap-detailed\"><details><summary class=\"detail-summary\">Detailed description<\/summary><p class=\"detailed\">The third component (C3) of the complement system plays an important role in the immune response to microbes like bacteria, fungi or parasites. The causative genetic variant prohibits the formation of functional C3 units and the chain of defence mechanisms is broken. Affected dogs exhibit higher susceptibility to infections. Glomerulonephritis, caused by C3-deficiency dependant cell death in the complement system, is often diagnosed for those dogs.<\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218184","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/218184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/comments?post=218184"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/218184\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/uk\/wp-json\/wp\/v2\/media?parent=218184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}