Progressive Retinaatrophie (crd3-PRA)
Progressive retinal atrophy (crd3-PRA)
General description
The retinal function of very young affected dogs is still normal. But at the age of 12-24 months, the cone and later also the rod photoreceptor cells begin to degenerate. Difficulties avoiding obstacles in dimlight are typical first signs of this disease. The degeneration of the photoreceptors progresses and results in complete blindness after several years.
Breeds
Irish Glen of Imaal Terrier
Order details
| Test number | 8691 |
| Abbreviation | crd3-PRA |
| Sample material | 0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT) |
| Test duration | 7-14 working days |
Test specifications
| Symptom complex | ophthalmic |
| Inheritance | autosomal recessive |
| Age of onset | 12-24 months |
| Causality | causally |
| Gene | ADAM9 |
| Mutation | DEL |
| Literature | OMIA:001520-9615 |
Detailed description
At the breed Irish Glen of Imaal Terrier, a variant of the ADAM9 gene has been found to correlate with cone-rod dystrophia (crd3). The retinal function of very young affected dogs is still normal. But at the age of 12-24 months, the cone and later also the rod photoreceptor cells begin to degenerate. Difficulties avoiding obstacles in dimlight are typical first signs of this disease. The degeneration of the photoreceptors progresses and results in complete blindness after several years. At ophthalmoscopic examinations, this type of PRA often not becomes evident until the age of 3-5 years.
