{"id":273148,"date":"2024-09-12T07:23:58","date_gmt":"2024-09-12T05:23:58","guid":{"rendered":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/malattie-ereditarie-cane\/musladin-lueke-syndrome-mls\/"},"modified":"2024-09-12T07:23:58","modified_gmt":"2024-09-12T05:23:58","slug":"musladin-lueke-syndrome-mls","status":"publish","type":"page","link":"https:\/\/labogen.com\/it\/malattie-ereditarie-cane\/musladin-lueke-syndrome-mls\/","title":{"rendered":"Musladin-Lueke syndrome (MLS)"},"content":{"rendered":"<div class=\"wrap-top\"><div class=\"wrap-left\"><h1 class=\"header-1\">Musladin-Lueke syndrome (MLS)<\/h1><h4><strong>General description<\/strong><\/h4><p class=\"bodytext\">Musladin-Lueke Syndrome (MLS) manifests with extensive fibrosis of the skin and joints. Arthrosis, stiffness, short outer digits as well as a typical flat head shape with higher ear set and slanted eyes are characteristic for this disease.  Affected dogs walk upright on their front feed in what resembles a ballerina stance. Additionally, they show a \u201chappy\u201d temperament.<\/p><h4 class=\"header-4\"><strong><span>Breeds<\/span><\/strong><\/h4><p>Beagle<\/p><\/div><div class=\"wrap-right\"><div class=\"wrap-toggle\"><div class=\"toggle-details\"><details><summary class=\"summary-details\">Order details<\/summary><table border=\"0\"><tr><td width=\"45%\"><span><strong>Test number<\/strong><\/span><\/td><td>8411<\/td><\/tr><tr><td><strong>Abbreviation<\/strong><\/td><td>MLS<\/td><\/tr><tr><td><strong>Sample material<\/strong><\/td><td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr><tr><td><strong>Test duration<\/strong><\/td><td>3-5 working days<\/td><\/tr><\/table><\/details><details><summary class=\"summary-specs\">Test specifications<\/summary><table border=\"0\"><tr><td width=\"45%\"><strong>Symptom complex<\/strong><\/td><td>skeletal<\/td><\/tr><tr><td width=\"45%\"><strong>Inheritance<\/strong><\/td><td>autosomal recessive<\/td><\/tr><tr><td width=\"45%\"><strong>Age of onset<\/strong><\/td><td>2-4 months<\/td><\/tr><tr><td width=\"45%\"><strong>Causality<\/strong><\/td><td>causally<\/td><\/tr><tr><td width=\"45%\"><strong>Gene<\/strong><\/td><td>ADAMTSL2<\/td><\/tr><tr><td width=\"45%\"><strong>Mutation<\/strong><\/td><td>C-T<\/td><\/tr><tr><td width=\"45%\"><strong>Literature<\/strong><\/td><td><a href='https:\/\/www.omia.org\/OMIA001509\/9615\/' target='_blank'>OMIA:001509-9615<\/a><\/td><\/tr><\/table><\/details><\/div><div class=\"order-now\"><strong><a href=\"https:\/\/shop.labogen.com\">Order now ...<\/a><\/strong><\/div><\/div><\/div><div class=\"clear-both\"><\/div><\/div><div class=\"wrap-detailed\"><details><summary class=\"detail-summary\">Detailed description<\/summary><p class=\"detailed\">Musladin-Lueke syndrome (MLS) manifests with extensive fibrosis of the skin and joints. As puppies, affected dogs fail to thrive. By one year of age the disease stabilizes whereby arthrosis, stiffness, short outer digits as well as a typical flat head shape with higher ear set and slanted eyes are characteristic for this disease. Affected dogs walk upright on their front feed in what resembles a ballerina stance. Additionally, they show a \u201chappy\u201d temperament.<\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":269239,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-273148","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/273148","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/comments?post=273148"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/273148\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/269239"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/media?parent=273148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}