{"id":272354,"date":"2024-09-12T07:23:59","date_gmt":"2024-09-12T05:23:59","guid":{"rendered":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/malattie-ereditarie-cane\/behaviour-propensity\/"},"modified":"2024-09-12T07:23:59","modified_gmt":"2024-09-12T05:23:59","slug":"behaviour-propensity","status":"publish","type":"page","link":"https:\/\/labogen.com\/it\/malattie-ereditarie-cane\/behaviour-propensity\/","title":{"rendered":"Behaviour propensity"},"content":{"rendered":"

Behaviour propensity<\/h1>

General description<\/strong><\/h4>

The Allele A22 of the dopamine transporter gene (SLC6A3) could be found more likely at Malinois that show unpredictable aggressions, while the alleles A0 and A10 could not be associated with this undesired behavior. Besides the desired controlled aggression that is provoked and clearly related to a well-defined situation (\u201ctargeted aggression\u201d), dogs with the Allele A22 often show unpredictable and uncontrollable aggressions, sometimes combined with seizures. <\/p>

Breeds<\/span><\/strong><\/h4>

Belgian Shepherd Dog, Malinois<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8614<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Causality<\/strong><\/td>correlated variant<\/td><\/tr>
Gene<\/strong><\/td>SLC6A3<\/td><\/tr>
Mutation<\/strong><\/td>COMPLEX<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002328-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

The Malinois is a variety of the Belgian Shepherd breed and is known to be an active, intelligent, hard-working dog which exhibits an exceptional high energy and awareness level. Due to these characteristics, the daily handling of the Malinois could be challenging for dog owners who are not prepared to provide the exercise they require. On the other hand, they make the Malinois an excellent working dog for personal protection, police work or sport (like agility or sport protection). <\/p>

Besides the desired controlled aggression that is provoked and clearly related to a well-defined situation (\u201ctargeted aggression\u201d), some owners reported that their Malinois showed unpredictable and episodic aggression<\/strong> that makes them difficult to handle and even dangerous. The undesired aggression is described as spontaneous and without any obvious trigger<\/strong>. During these phases of aggression, dogs are completely out of control and their eyes are \u201cglazing over\u201d<\/strong>. They do not respond to environmental stimuli anymore, show owner-directed biting behaviour<\/strong> or even seizures<\/strong>.<\/p>

A tandem repeat variant in the dopamine transporter gene (SLC6A3<\/em>)<\/strong> has been found to be more likely present at dogs that show this \u201cunpredictable aggression\u201d<\/strong>. Three possible alleles of the gene have been identified: The alleles A0 and A10 are not associated with adverse behaviour<\/strong>, while the allele A22 is associated with \u201cundesirable aggression\u201d<\/strong>. Dogs that are heterozygous for A22 (A0\/A22 or A10\/A22) are reported to show behaviour considered by some owners to be adverse and\/or potentially undesirable. However, dogs with the most extreme behaviour are more likely to have the homozygous genotype A22\/A22.<\/p>

Please note that behaviour is composed with many other factors that could influence or trigger aggressive behaviour (e.g. painful diseases, persistent environmental stress or inappropriate educational methods) besides to this genetic variant. Moreover, this test only provides information about a single genetic predisposition of the dog. This result does not allow any presumption about the actually trainability or communicative behaviour of the dog. <\/p>


Genotype (alleles)<\/th> Association with behaviour<\/th> Description<\/th> <\/tr> <\/thead>
A0 \/ A0<\/td> Not associated with adverse behaviour<\/td> No reported association with \u201cundesirable aggression\u201d.<\/td> <\/tr>
A10 \/ A10<\/td> Not associated with adverse behaviour<\/td> No reported association with \u201cundesirable aggression\u201d.<\/td> <\/tr>
A0 \/ A10<\/td> Not associated with adverse behaviour<\/td> Both alleles are reported as not associated with adverse behaviour.<\/td> <\/tr>
A0 \/ A22<\/td> Associated with undesirable aggression<\/td> Some dogs are reported to show behaviour considered adverse and\/or potentially undesirable.<\/td> <\/tr>
A10 \/ A22<\/td> Associated with undesirable aggression<\/td> Some dogs are reported to show behaviour considered adverse and\/or potentially undesirable.<\/td> <\/tr>
A22 \/ A22<\/td> Higher likelihood of extreme undesirable aggression<\/td> Dogs with the most extreme behaviour are more likely to have this genotype.<\/td> <\/tr> <\/tbody> <\/table><\/p> <\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":269239,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-272354","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/272354","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/comments?post=272354"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/272354\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/269239"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/media?parent=272354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}