{"id":218805,"date":"2024-09-12T07:23:51","date_gmt":"2024-09-12T05:23:51","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/dyserythropoetische-anaemie-und-myopathie-dams"},"modified":"2024-09-12T07:23:51","modified_gmt":"2024-09-12T05:23:51","slug":"dyserythropoetische-anaemie-und-myopathie-dams","status":"publish","type":"page","link":"https:\/\/labogen.com\/it\/erbkrankheiten-hund\/dyserythropoetische-anaemie-und-myopathie-dams\/","title":{"rendered":"Dyserythropoetische An\u00e4mie und Myopathie (DAMS)"},"content":{"rendered":"

Dyserythropoietic anaemia and myopathy (DAMS)<\/h1>

General description<\/strong><\/h4>

Genetic variants of the EHBP1L1 gene cause DAMS in the breeds Labrador Retriever and English Springer Spaniel. Clinical symptoms are muscle atrophy, pelvic limb weakness and regurgitation. English Springer Spaniels also show anaemia and cardiomyopathy. Despite the variable clinical symptoms both breeds showed similar changes in erythrocyte morphology and muscle histopathology.<\/p>

Breeds<\/span><\/strong><\/h4>

Australian-Labradoodle (Cobberdog), English Springer Spaniel, Labradoodle, Labrador Retriever<\/p>

Detailed description<\/summary>

<\/p><\/details><\/div><\/div>

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Dyserythropoietic anemia and myopathy (DAMS) - English Springer Spaniel<\/h4>

A variant in the EHBP1L1<\/em> gene<\/strong> was found to cause DAMS in the breed English Springer Spaniel<\/strong>. In this breed, the disease shows an early onset<\/strong> of anaemia, megaoesophagus, cardiomyopathy and generalized slowly progressive muscle atrophy<\/strong>. Blood examination showed marked microcytosis, inappropriate metarubricytosis, erythrocyte abnormalities and mild anemia. <\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8805<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>EHBP1L1<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002564-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Dyserythropoietic anemia and myopathy (DAMS) - Labrador Retriever<\/h4>

A genetiv variant of the EHBP1L1<\/em> gene<\/strong> was found to cause Dyserythropoietic anemia and myopathy (DAMS) in the breed Labrador Retriever<\/strong>. Clinical symptoms are muscle atrophy, pelvic limb weakness and regurgitation<\/strong>. Blood examination showed marked microcytosis, inappropriate metarubricytosis, erythrocyte abnormalities and mild anemia. Signs of myopathy including megaoesophagus were detected at approximately 5 years of age<\/strong>, but affected dogs showed a history of microcytosis and erythrocyte abnormalities.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8805<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>EHBP1L1<\/td><\/tr>
Mutation<\/strong><\/td>G-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002564-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
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