{"id":218605,"date":"2024-09-12T07:23:50","date_gmt":"2024-09-12T05:23:50","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/neuralrohrdefekt-ntd"},"modified":"2024-09-12T07:23:50","modified_gmt":"2024-09-12T05:23:50","slug":"neuralrohrdefekt-ntd","status":"publish","type":"page","link":"https:\/\/labogen.com\/it\/erbkrankheiten-hund\/neuralrohrdefekt-ntd\/","title":{"rendered":"Neuralrohrdefekt (NTD)"},"content":{"rendered":"

Spinal dysraphism (NTD)<\/h1>

General description<\/strong><\/h4>

Neural tube defects result from abnormal closure or development of the neuronal tube during embryogenesis. A genetic variant has been found to cause spinal dysraphism, which is a non-progressiv ataxia and is characterised by the following symptoms: abnormal hair streams along the back, kinked tails, scoliosis in the lumbar spinal region, paraparesis, \u201cbunny-hopping\u201d, crouched stance. <\/p>

Breeds<\/span><\/strong><\/h4>

Weimaraner<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8605<\/td><\/tr>
Abbreviation<\/strong><\/td>NTD<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>morphological<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>NKX2-8<\/td><\/tr>
Mutation<\/strong><\/td>COMPLEX<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000938-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Neural tube defects result from abnormal closure or development of the neuronal tube during embryogenesis. In the Weimaraner breed, a mutation of the regulatory homebox gene NKX2-8, which is expressed in the developing tube, could be found to be associated with the neural tube defect, termed spinal dysraphism. The spinal dysraphism is a non-progressiv ataxia and is characterised by the following symptoms: abnormal hair streams along the back, kinked tails, scoliosis in the lumbar spinal region, paraparesis, \u201cbunny-hopping\u201d, crouched stance.<\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218605","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/218605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/comments?post=218605"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/218605\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/media?parent=218605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}