{"id":218479,"date":"2024-09-12T07:23:50","date_gmt":"2024-09-12T05:23:50","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/alaskan-malamute-polyneuropathie-ampn"},"modified":"2024-09-12T07:23:50","modified_gmt":"2024-09-12T05:23:50","slug":"alaskan-malamute-polyneuropathie-ampn","status":"publish","type":"page","link":"https:\/\/labogen.com\/it\/erbkrankheiten-hund\/alaskan-malamute-polyneuropathie-ampn\/","title":{"rendered":"Alaskan Malamute Polyneuropathie (AMPN)"},"content":{"rendered":"

Alaskan Malamute polyneuropathy (AMPN)<\/h1>

General description<\/strong><\/h4>

Polyneuropathy causes undersupply of the peripheric nervous system followed by nerve degeneration and gradually muscle atrophy. The onset of clinical symptoms occurs during the first two years of a dog's life including progressive myasthenia, exercise intolerance, loss of reflexes and ataxia of all limbs and if the larynx is affected changes in voice and regurgitation. The general condition is not incfluenced. <\/p>

Breeds<\/span><\/strong><\/h4>

Alaskan Malamute<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8479<\/td><\/tr>
Abbreviation<\/strong><\/td>AMPN<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>3-5 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>neurological<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>NDRG1<\/td><\/tr>
Mutation<\/strong><\/td>C-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002120-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Polyneuropathy causes undersupply of the peripheric nervous system followed by nerve degeneration. Due to the lack of nervous stimulation the muscles degrade gradually.<\/p>

The causal genetic variant in Alaskan Malamute differs from the known variant in Greyhound breed. The onset of clinical symptoms occurs during the first two years of a dog\u00b4s life. These symptoms include progressive muscle weekness (amyosthenia), exercise intolerance, loss of reflexes and ataxia of all limbs. So, the dog may fall down, walk on the tops of his feet or his gait may just look a little off. When palsy affects the larynx, changes in voice and problems in swallowing and regurgitating have also been described. The general condition is not influenced by the disease.<\/p>

There are some other spinal or neurological diseases that may cause similar symptoms, so it may often be misdiagnosed or undiagnosed.<\/p><\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218479","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/218479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/comments?post=218479"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/218479\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/it\/wp-json\/wp\/v2\/media?parent=218479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}