{"id":218452,"date":"2024-09-12T07:23:50","date_gmt":"2024-09-12T05:23:50","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/primaeres-weitwinkel-glaukom-poag"},"modified":"2024-09-12T07:23:50","modified_gmt":"2024-09-12T05:23:50","slug":"primaeres-weitwinkel-glaukom-poag","status":"publish","type":"page","link":"https:\/\/labogen.com\/it\/erbkrankheiten-hund\/primaeres-weitwinkel-glaukom-poag\/","title":{"rendered":"Prim\u00e4res Weitwinkel-Glaukom (POAG)"},"content":{"rendered":"

Primary open angle glaucoma (POAG)<\/h1>

General description<\/strong><\/h4>

A primary open angle glaucoma is a genetic dysfunction of the connective tissue in the eye. The onset of the disease varies between breeds.<\/p>

Breeds<\/span><\/strong><\/h4>

Basset Fauve de Bretagne, Basset Hound, Beagle, East Siberian Laika, Norwegian Elkhound , Petit Basset Griffon Vendeen<\/p>

Detailed description<\/summary>

A primary open angle glaucoma is a genetic dysfunction of the connective tissue in the eye. Thereby, the aqueous fluid is blocked and the pressure of the eyeball rises. Ultimately, the optic nerve and the retina are damaged leading from partial to complete blindness. Symptoms include widened pupils, red eyeballs, cloudy cornea and increased eye pressure. Raising eye-pressure causes pain, which leads to the dog loses its appetite, scratches the eyes, rubbing its head on walls and exhibit aggressive behaviour. Early diagnosis allows treatment in decreasing the eye-pressure constantly and thereby preventing damage on the optic nerve and retina. The onset of the disease varies between breeds. <\/p><\/details><\/div><\/div>

<\/div><\/div>

Primary Open Angle Glaucoma (POAG) - Beagle and East Siberian Laika<\/h4>

First symptoms in the Beagle are shown between eight and sixteen months.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8452<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>ophthalmic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>8-16 months<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>ADAMTS10<\/td><\/tr>
Mutation<\/strong><\/td>C-T<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001870-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Primary Open Angle Glaucoma (POAG) - Norwegian Elkhound <\/h4>

First symptoms emerge at a middle to later age. <\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8452<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>ophthalmic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>adulthood<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>ADAMTS10<\/td><\/tr>
Mutation<\/strong><\/td>C-T<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001870-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Primary Open Angle Glaucoma (POAG) - Petit Basset Griffon Vendeen<\/h4>

In the breed Petit Basset Griffon Vendeen, POAG causes a small, sustained rise in intraocular pressure (IOP) and lens subluxation. First clinical signs emerge at the age of 3-4 years and develop progressively. In later stages of the disease, globe enlargement, retinal degeneration and optic disc deformation could be observed. Since POAG does not cause pain in this breed, ownes only become aware of the disease as soon as the globe enlargement and the vision problems become noticeable. <\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8452<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>ophthalmic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>3-4 years <\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>ADAMTS17<\/td><\/tr>
Mutation<\/strong><\/td>COMPLEX<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001976-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Primary Open Angle Glaucoma (POAG) - Basset Fauve de Bretagne<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8452<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>ophthalmic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>ADAMTS17<\/td><\/tr>
Mutation<\/strong><\/td>G-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001976-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Primary Open Angle Glaucoma (POAG) - Basset Hound<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8452<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>ophthalmic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>ADAMTS17<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001976-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
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