{"id":286267,"date":"2026-01-14T14:58:34","date_gmt":"2026-01-14T13:58:34","guid":{"rendered":"https:\/\/labogen.com\/maladies-hereditaires-chien\/primary-hyperparathyroidism-phpt\/"},"modified":"2026-02-09T12:44:43","modified_gmt":"2026-02-09T11:44:43","slug":"primary-hyperparathyroidism-phpt","status":"publish","type":"page","link":"https:\/\/labogen.com\/fr\/maladies-hereditaires-chien\/primary-hyperparathyroidism-phpt\/","title":{"rendered":"Primary hyperparathyroidism (PHPT)"},"content":{"rendered":"

Primary hyperparathyroidism (PHPT)<\/h1>

General description<\/strong><\/h4>

Primary hyperparathyroidism (PHPT) is a hereditary condition in which the regulation of calcium levels is impaired. Affected dogs produce parathyroid hormone uncontrollably, leading to persistently elevated blood calcium levels, loss of calcium from the bones, and potentially bone weakness and kidney problems up to and including renal failure. The condition typically develops only after the age of eight years and is inherited in an autosomal dominant manner.<\/p>

Breeds<\/span><\/strong><\/h4>

German Spitz, Keeshond<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8976<\/td><\/tr>
Abbreviation<\/strong><\/td>PHPT<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal dominant<\/td><\/tr>
Age of onset<\/strong><\/td>about 8 years<\/td><\/tr>
Gene<\/strong><\/td>SIRT6<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000508-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
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Detailed description<\/summary>

Primary hyperparathyroidism (PHPT) is an inherited condition that leads to a disruption of the regulation of calcium levels in the body<\/strong>. Normally, the parathyroid hormone (PTH)<\/strong> is released when the calcium level in the blood is too low. It causes calcium to be released from the bones, reduces the amount of calcium excreted by the kidneys, and lowers the phosphate level. In affected dogs, however, parathyroid hormone is produced in an uncontrolled way. As a result, the calcium level in the blood remains permanently elevated (hypercalcaemia)<\/strong>, while at the same time calcium is lost from the bones<\/strong>. Possible consequences include progressive weakening of the bones, kidney problems up to kidney failure, as well as other metabolic disorders<\/strong>.<\/p>

In the Keeshond dog (German Spitz), a genetic variant in the SIRT6<\/em> gene (Sirtuin-6)<\/strong> has been identified that is associated with this condition. This variant changes the structure of an important protein and impairs its function. The variant is inherited in an autosomal dominant<\/strong> manner, meaning that just one altered copy of the gene is sufficient for a dog to develop the disease. Both dogs with one altered gene copy (N\/PHPT) and dogs with two altered gene copies (PHPT\/PHPT) may develop symptoms.<\/p>

The condition typically appears later in life, usually after the age of 8 years<\/strong>. Many affected dogs show no obvious symptoms even up to the age of 9\u201310 years. Genetic testing allows early identification of affected animals and supports appropriate breeding decisions.<\/p>

In addition, another variant in the promoter region of the EEF2 gene (eukaryotic elongation factor 2) has been described, which may influence the activity of the gene. This variant has been used for genetic testing in the USA since 2008. However, whether it is reliably associated with the condition outside the Keeshond (Spitz) breed or outside the US population is currently not clearly established.<\/p><\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":269880,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-286267","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/286267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/comments?post=286267"}],"version-history":[{"count":1,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/286267\/revisions"}],"predecessor-version":[{"id":286271,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/286267\/revisions\/286271"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/269880"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/media?parent=286267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}