{"id":282115,"date":"2025-07-10T12:50:28","date_gmt":"2025-07-10T10:50:28","guid":{"rendered":"https:\/\/labogen.com\/?page_id=282115"},"modified":"2025-07-22T14:25:39","modified_gmt":"2025-07-22T12:25:39","slug":"muscular-dystrophy-duchenne-type-cavalier-king-charles-spaniel","status":"publish","type":"page","link":"https:\/\/labogen.com\/fr\/maladies-hereditaires-chien\/muscular-dystrophy-duchenne-type-cavalier-king-charles-spaniel\/","title":{"rendered":"Muscular dystrophy (Duchenne type) \u2013 Cavalier King Charles Spaniel"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"282115\" class=\"elementor elementor-282115 elementor-282109\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6903062e e-flex e-con-boxed e-con e-parent\" data-id=\"6903062e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-40fa31e3 e-con-full e-flex e-con e-child\" data-id=\"40fa31e3\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5d7829b1 elementor-widget elementor-widget-heading\" data-id=\"5d7829b1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Muscular dystrophy (Duchenne type) - Cavalier King Charles Spaniel<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d8e8d5b elementor-widget elementor-widget-text-editor\" data-id=\"1d8e8d5b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4><strong>General description<\/strong><\/h4><p><span style=\"color: #800000;\">In the Cavalier King Charles Spaniel breed, a genetic variant was found in Exon 42 of the DMD (Duchenne muscular dystrophy) gene, which is associated with muscular dystrophy. Affected puppies are smaller than their siblings and cannot swallow and chew properly. At about 3 months of age, symptoms such as general muscle weakness, difficulty swallowing (dysphagia), increased saliva flow (ptyalism), nasal congestion, cough, fatigue and lethargy, enlarged tongue (macroglossia), excessive stretching of the carpal joints, a bonny-hopping gait and collapse after a few minutes of movement can be observed, too.<\/span><\/p><p><span style=\"color: #800000;\">The variant in Exon 42 is located in a secondary hotspot for muscular dystrophy and is inherited in independently of the variant in intron 50, which is also occurring in this breed.<\/span><\/p><h4><strong><span style=\"color: #e51e1e;\">Breeds<\/span><\/strong><\/h4><p>Cavalier King Charles Spaniel<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1ae50188 e-con-full e-flex e-con e-child\" data-id=\"1ae50188\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6ca5da92 elementor-widget elementor-widget-toggle\" data-id=\"6ca5da92\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;,&quot;_animation_delay&quot;:1500}\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<h6 id=\"elementor-tab-title-1821\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1821\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-caret-right\" viewBox=\"0 0 192 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M0 384.662V127.338c0-17.818 21.543-26.741 34.142-14.142l128.662 128.662c7.81 7.81 7.81 20.474 0 28.284L34.142 398.804C21.543 411.404 0 402.48 0 384.662z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-caret-down\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Order details<\/a>\n\t\t\t\t\t<\/h6>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1821\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1821\"><table border=\"0\"><tbody><tr><td width=\"45%\"><span style=\"color: #e51e1e;\"><strong>Test number<\/strong><\/span><\/td><td>Only included in <a href=\"https:\/\/labogen.com\/en\/labogenetics-xxl-dog\/\">LABOGeneticsXXL \u2013 Dog<\/a><\/td><\/tr><tr><td><strong>Abbreviation<\/strong><\/td><td>MD2<\/td><\/tr><\/tbody><\/table><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<h6 id=\"elementor-tab-title-1822\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1822\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><svg class=\"e-font-icon-svg e-fas-caret-right\" viewBox=\"0 0 192 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M0 384.662V127.338c0-17.818 21.543-26.741 34.142-14.142l128.662 128.662c7.81 7.81 7.81 20.474 0 28.284L34.142 398.804C21.543 411.404 0 402.48 0 384.662z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><svg class=\"elementor-toggle-icon-opened e-font-icon-svg e-fas-caret-down\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Test specifications<\/a>\n\t\t\t\t\t<\/h6>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1822\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1822\"><table border=\"0\"><tbody><tr><td width=\"45%\"><span style=\"color: #e51e1e;\"><strong>Inheritance<\/strong><\/span><\/td><td>X-chromosomal recessive<\/td><\/tr><tr><td><strong>Gene<\/strong><\/td><td>DMD<\/td><\/tr><tr><td><span style=\"color: #e51e1e;\"><strong>Mutation<\/strong><\/span><\/td><td>DEL<\/td><\/tr><tr><td><strong>Literature<\/strong><\/td><td><a href=\"https:\/\/omia.org\/OMIA001081\/9615\/\">OMIA:001081-9615<\/a><\/td><\/tr><\/tbody><\/table><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f968e0 elementor-align-right elementor-widget elementor-widget-ibutton\" data-id=\"0f968e0\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;,&quot;_animation_delay&quot;:3000}\" data-widget_type=\"ibutton.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ot-button\">\r\n\t\t\t<a href=\"https:\/\/labogen.com\/en\/labogenetics-xxl-dog\/\" class=\"octf-btn octf-btn-dark\"><strong>View LABOGenetics XXL Dog here<\/strong><\/a>\r\n\t    <\/div>\r\n\t    \t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f9ddd7e e-flex e-con-boxed e-con e-parent\" data-id=\"f9ddd7e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ca865d5 elementor-widget elementor-widget-spacer\" data-id=\"ca865d5\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1278d38d e-flex e-con-boxed e-con e-parent\" data-id=\"1278d38d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-26903a1 elementor-widget elementor-widget-spacer\" data-id=\"26903a1\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Muscular dystrophy (Duchenne type) &#8211; Cavalier King Charles Spaniel General description In the Cavalier King Charles Spaniel breed, a genetic variant was found in Exon 42 of the DMD (Duchenne muscular dystrophy) gene, which is associated with muscular dystrophy. Affected puppies are smaller than their siblings and cannot swallow and chew properly. At about 3 [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":270998,"parent":269880,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-282115","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/282115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/comments?post=282115"}],"version-history":[{"count":5,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/282115\/revisions"}],"predecessor-version":[{"id":282137,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/282115\/revisions\/282137"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/269880"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/media\/270998"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/media?parent=282115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}