{"id":281939,"date":"2025-07-10T07:13:47","date_gmt":"2025-07-10T05:13:47","guid":{"rendered":"https:\/\/labogen.com\/?page_id=281939"},"modified":"2025-07-10T07:13:48","modified_gmt":"2025-07-10T05:13:48","slug":"atherosclerosis-ath","status":"publish","type":"page","link":"https:\/\/labogen.com\/fr\/maladies-hereditaires-chat\/atherosclerosis-ath\/","title":{"rendered":"Atherosclerosis (ATH)"},"content":{"rendered":"<div class=\"wrap-top\"><div class=\"wrap-left\"><h1 class=\"header-1\">Atherosclerosis (ATH)<\/h1><h4><strong>General description<\/strong><\/h4><p class=\"bodytext\">Atherosclerosis is a chronic inflammatory vascular disease initiated by the accumulation ofLDL-derived cholesterol on the arterial inner surface.<\/p><h4 class=\"header-4\"><strong><span>Breeds<\/span><\/strong><\/h4><p>Korat<\/p><\/div><div class=\"wrap-right\"><div class=\"wrap-toggle\"><div class=\"toggle-details\"><details><summary class=\"summary-details\">Order details<\/summary><table border=\"0\"><tr><td width=\"45%\"><span><strong>Test number<\/strong><\/span><\/td><td>8946<\/td><\/tr><tr><td><strong>Sample material<\/strong><\/td><td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr><tr><td><strong>Test duration<\/strong><\/td><td>7-14 working days<\/td><\/tr><\/table><\/details><details><summary class=\"summary-specs\">Test specifications<\/summary><table border=\"0\"><tr><td width=\"45%\"><strong>Inheritance<\/strong><\/td><td>autosomal recessive<\/td><\/tr><\/table><\/details><\/div><div class=\"order-now\"><strong><a href=\"https:\/\/shop.labogen.com\">Order now ...<\/a><\/strong><\/div><\/div><\/div><div class=\"clear-both\"><\/div><\/div><div class=\"wrap-detailed\"><details><summary class=\"detail-summary\">Detailed description<\/summary><p class=\"detailed\"><p><strong>Atherosclerosis<\/strong> is a <strong>chronic inflammatory vascular disease<\/strong> initiated by the <strong>accumulation of LDL-derived cholesterol<\/strong> on the arterial inner surface. <\/p><p>In the breed <strong>Korat<\/strong>, a genetic variant of the <em><strong>LDLR<\/strong> <\/em><strong>gene <\/strong>is associated with spontaneous atherosclerosis, characterized by severe <strong>hypercholesterolemia (high levels of cholesterol in the blood)<\/strong> and clinical signs of <strong>congestive heart failure<\/strong>, ultimately<strong> leading to death<\/strong>. Histopathological examination revealed atherosclerotic lesions, especially in large elastic arteries and coronary arteries. There is evidence that endothelial disruption may predispose affected cats to <strong>thrombosis<\/strong>. <\/p><p><strong>Clinical signs<\/strong> of atherosclerosis appear <strong>not until middle and advanced ages<\/strong>, since affected cats experience a silent progression of the disease over several years.<\/p><\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":15,"featured_media":0,"parent":269876,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-281939","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/281939","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/comments?post=281939"}],"version-history":[{"count":1,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/281939\/revisions"}],"predecessor-version":[{"id":281943,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/281939\/revisions\/281943"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/269876"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/media?parent=281939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}